Blood Gas

Blood Gas Interpretation

Systematic approach to arterial, venous, and capillary blood gases

Systematic Approach

  1. 1
    Check the pH — Acidosis (<7.35) or Alkalosis (>7.45)?
  2. 2
    Check the PaCO2 — Respiratory cause? High CO2 = respiratory acidosis. Low CO2 = respiratory alkalosis.
  3. 3
    Check the HCO3/BE — Metabolic cause? Low HCO3 = metabolic acidosis. High HCO3 = metabolic alkalosis.
  4. 4
    Compensation? — Is the other system trying to compensate?
  5. 5
    Check PaO2 — Hypoxaemia (<10 kPa on arterial)? Type 1 vs Type 2 respiratory failure?
  6. 6
    Check Lactate — Elevated (>2 mmol/L)? Tissue hypoperfusion?

Respiratory Failure

Type 1

Hypoxaemia WITHOUT hypercapnia

PaO2 <8 kPa

PaCO2 normal or low

Type 2

Hypoxaemia WITH hypercapnia

PaO2 <8 kPa

PaCO2 >6.0 kPa

Neuroprotection Blood Gas Targets

Parameter Target
PaO2>8 kPa
PaCO24.5–5.2 kPa
ICP<20 mmHg
CPP (<6 yrs)>40 mmHg
CPP (>6 yrs)>50 mmHg

⚠ Avoid hyperventilation — low CO2 causes cerebral vasoconstriction