Blood Gas Interpretation
Systematic approach to arterial, venous, and capillary blood gases
Systematic Approach
- 1 Check the pH — Acidosis (<7.35) or Alkalosis (>7.45)?
- 2 Check the PaCO2 — Respiratory cause? High CO2 = respiratory acidosis. Low CO2 = respiratory alkalosis.
- 3 Check the HCO3/BE — Metabolic cause? Low HCO3 = metabolic acidosis. High HCO3 = metabolic alkalosis.
- 4 Compensation? — Is the other system trying to compensate?
- 5 Check PaO2 — Hypoxaemia (<10 kPa on arterial)? Type 1 vs Type 2 respiratory failure?
- 6 Check Lactate — Elevated (>2 mmol/L)? Tissue hypoperfusion?
Respiratory Failure
Type 1
Hypoxaemia WITHOUT hypercapnia
PaO2 <8 kPa
PaCO2 normal or low
Type 2
Hypoxaemia WITH hypercapnia
PaO2 <8 kPa
PaCO2 >6.0 kPa
Neuroprotection Blood Gas Targets
| Parameter | Target |
|---|---|
| PaO2 | >8 kPa |
| PaCO2 | 4.5–5.2 kPa |
| ICP | <20 mmHg |
| CPP (<6 yrs) | >40 mmHg |
| CPP (>6 yrs) | >50 mmHg |
⚠ Avoid hyperventilation — low CO2 causes cerebral vasoconstriction